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Immunology news
Oncology & Cancer
New technique improves T cell-based immunotherapies for solid tumors
Scientists from Scripps Research have enhanced an existing immunotherapy by removing the sugar coating surrounding solid tumors—such as in melanoma, breast, and prostate cancer—so T cells can more effectively kill tumor ...
2 hours ago
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Immunology
Experimental vaccine targets portions of the flu virus that don't change
Duke researchers have opened a new avenue in the attack against influenza viruses by creating a vaccine that encourages the immune system to target a portion of the virus surface that is less variable.
3 hours ago
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New mRNA cancer vaccine triggers fierce immune response to fight malignant brain tumor
In a first-ever human clinical trial of four adult patients, an mRNA cancer vaccine developed at the University of Florida quickly reprogrammed the immune system to attack glioblastoma, the most aggressive and lethal brain ...
6 hours ago
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Scientists identify new brain circuit in mice that controls body's inflammatory reactions
The brain can direct the immune system to an unexpected degree, capable of detecting, ramping up and tamping down inflammation, shows a new study in mice from researchers at Columbia's Zuckerman Institute.
6 hours ago
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Researchers find difference in pancreatic cancer cells, offering new hope for immunotherapy effectiveness
A new study has found that pancreatic cancer cells are different based on their location in the pancreas, providing new information about tumors that could lead to better targeted treatments.
8 hours ago
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Patients with rheumatoid arthritis have unique and complex autoantibody patterns, study reveals
Patients with rheumatoid arthritis (RA) all have a unique and diverse set of antibodies that are involved in the development of the disease. Researchers at Utrecht University unveiled the complexity of these antibodies using ...
17 hours ago
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For parents of kids with food allergies, social media can bring support—and stress
Having a child with food allergies isn't easy to manage, and now new research shows that most of these parents turn to social media for medical advice.
7 hours ago
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Gene expression analyses identify potential drivers of chronic allergic inflammation
Currently, most therapies for allergic diseases require lifelong treatment. Allergic reactions, characterized by ongoing (type 2) inflammation in response to chronic antigen exposure, underlie many chronic diseases in humans, ...
Apr 30, 2024
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Study finds some people have a uniquely human gene that enhances immune function
University at Buffalo researchers have found that the active form of a gene promotes a broad range of protective traits. The gene is found in 75% of the population and is known to protect against neurodegeneration. Now, UB ...
Apr 30, 2024
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Study finds Bcl6 protein is an important transcription factor for formation of certain dendritic cells
While previous studies have investigated the function of the protein Bcl6 in dendritic cells—in some cases with varying results—a new study published in Nature Communications has sought to harmonize the sometimes contradictory ...
Apr 30, 2024
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Study highlights importance of early interventions to combat HIV
A study has compared the development of HIV reservoirs—locations in the body where the virus persists in a latent state—between patients who receive either early or late medical interventions. The findings highlight the ...
Apr 30, 2024
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Development in cancer treatment focuses on re-educating cells to combat resistance
In a development in cancer research, scientists are exploring new therapeutic strategies that move beyond traditional cytotoxic treatments, which have historically targeted uncontrolled cell proliferation.
Apr 30, 2024
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Targeting protein interactions may boost antitumor immunity in breast cancer
A multi-institutional team of investigators has discovered that targeting a specific protein interaction within immunosuppressive breast cancer cells may increase antitumor immune responses in otherwise difficult to treat ...
Apr 30, 2024
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New gene signature could transform immunotherapy for gastrointestinal cancers
Despite significant progress in treating gastrointestinal (GI) cancers through surgical resection, chemotherapy, radiotherapy, and targeted therapy, the objective response rate (ORR) for immune checkpoint inhibitor (ICI) ...
Apr 30, 2024
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Unlocking the immune system: cGAS-STING pathway offers new hope for cancer treatment
Cancer immunotherapy, which leverages the body's immune system to target tumors, has emerged as a pivotal strategy in oncology. This paradigm shift from conventional treatments offers a more precise method to neutralize cancer ...
Apr 30, 2024
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New method rapidly reveals how protein modifications power T cells
Imagine riding a bike. Now imagine riding a bike with an enormous beach ball stuck on your handlebars. That "modification" might change your experience quite a bit. In our cells, molecules called phosphate groups are constantly ...
Apr 29, 2024
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Protein responsible for genetic inflammatory disease identified
A team of researchers led by Dr. Hirotsugu Oda at the University of Cologne's CECAD Cluster of Excellence for Aging Research has discovered the role a specific protein complex plays in certain forms of immune dysregulation. ...
Apr 29, 2024
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Cancer cell–immune cell interactions can predict immunotherapy response
By examining which genes were turned on and off in a mix of cell types from breast cancer biopsies, a team led by UT Southwestern Medical Center researchers developed a tool that can accurately predict which patients with ...
Apr 29, 2024
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Researchers discover enzymes that open new path to universal donor blood
The quest to develop universal donor blood has taken a decisive step forward. Researchers at DTU and Lund University have discovered enzymes that, when mixed with red blood cells, are able to remove specific sugars that make ...
Apr 29, 2024
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Scientists develop new organoid model to study thymus function
Researchers from the Organoid group have developed a new organoid model that can be used to study the thymus. The organoids are derived from mouse thymus tissue, specifically model thymic epithelial cells (TECs). These cells ...
Apr 29, 2024
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