Key milestone for brown fat research with a ground-breaking MRI scan

Key milestone for brown fat research with a ground-breaking MRI scan
This is a digitally-enhanced axial MRI of the upper chest (as if viewed from the feet). Areas of potential brown fat are shown in green. Credit: University of Warwick

The first MRI scan to show 'brown fat' in a living adult could prove to be an essential step towards a new wave of therapies to aid the fight against diabetes and obesity.

Researchers from Warwick Medical School and University Hospitals Coventry and Warwickshire NHS Trust used a (MRI) based method to identify and confirm the presence of in a living adult.

Brown fat has become a hot topic for scientists due its ability to use energy and burn calories, helping to keep weight in check. Understanding the tissue and how it can be used to such ends is of growing interest in the search to help people suffering from obesity or at a high risk of developing diabetes.

Dr Thomas Barber, from the Department of Metabolic and Vascular Health at Warwick Medical School, explained, "This is an exciting area of study that requires further research and discovery. The potential is there for us to develop safe and effective ways of activating this brown fat to promote weight loss and increase energy expenditure – but we need more data to be able to get to that point."

"This particular proof of concept is key, as it allows us to pursue MRI techniques in future assessments and gather this required information."

The study, published in The Journal of Clinical Endocrinology and Metabolism, outlines the benefits of using MRI scans over the existing method of (PET). Whilst PET does show brown fat activity, it is subject to a number of limitations including the challenge of signal variability from a changing environmental temperature.

Unlike the PET data which only displays activity, the MRI can show brown fat content whether active or not – providing a detailed insight into where it can be found in the adult body. This information could prove vital in the creation of future therapies that seek to activate deposits of brown fat.

Dr Barber added, "The MRI allows us to distinguish between the brown fat, and the more well-known white fat that people associate with weight gain, due to the different water to fat ratio of the two tissue types. We can use the scans to highlight what we term 'regions of interest' that can help us to build a picture of where the brown fat is located."

With the proof of concept now completed, the next step is to further validate this technique across a larger group of adults.

Citation: Key milestone for brown fat research with a ground-breaking MRI scan (2014, April 17) retrieved 28 March 2024 from https://medicalxpress.com/news/2014-04-key-milestone-brown-fat-ground-breaking.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Researchers identify specific causes of brown fat cell 'whitening'

 shares

Feedback to editors