Scientists discover possible 'obesity gene'

UBC scientists discover possible 'obesity gene'
When scientists silenced the 'obesity gene' in mice, fat cells were 50 per cent smaller. (left vs. right) Credit: Gareth Lim, UBC

Scientists at the University of British Columbia have discovered a gene that could be an important cause of obesity.

The gene, which encodes a protein called 14-3-3ζ (zeta), is found in every cell of the body. But when scientists silenced the gene in mice, it resulted in a 50 per cent reduction in the amount of a specific kind of unhealthy "" - the kind associated with obesity, heart disease and diabetes. The fat reduction occurred despite the mice consuming the same amount of food. Mice that were bred to have higher levels of the 14-3-3zeta protein were noticeably bigger and rounder, having an average of 22 per cent more white fat when fed a .

Earlier this year, a consortium of scientists found over 100 regions on the human genome that correlate with obesity, likely through regulating the brain's perception of hunger and the distribution of fat throughout the body. That study, however, did not identify the gene that encodes 14-3-3zeta, which controls the production of (known as adipogenesis) and the growth of those cells.

Discovery of this direct link between a protein and , described in Nature Communications, points the way to a possible drug therapy. Scientists theorize that by suppressing the gene or blocking the protein, they could prevent in people who are overweight, or are on their way to becoming so.

"People gain fat in two ways - through the multiplication of their fat cells, and through the expansion of individual fat cells," said Gareth Lim, a postdoctoral fellow in UBC's Life Sciences Institute. "This protein affects both the number of cells and how big they are, by playing a role in the growth cycle of these cells."

Lim and James Johnson, a professor of cellular and physiological sciences, began investigating the 14-3-3 family of proteins four years ago as it often shows up in the unhealthy fat tissue of obese people. This study not only identified zeta as the operative , but demonstrated a clear cause-and-effect between 14-3-3zeta and fat accumulation.

"Until now, we didn't know how this gene affected obesity," Johnson said. "This study shows how fundamental research can address major health problems and open up new avenues for drug discovery."

Obesity is linked to increased risk of diabetes, , and some forms of cancer. Worldwide, obesity costs society $2 trillion each year. More than one in four Canadians are obese, and that number continues to grow, according to Statistics Canada. Alarmingly, the obesity rate is also increasing in children.

We don't fully understand how fat cells are made, and its clear that this information would be useful in efforts to prevent .

More information: 14-3-3ζ coordinates adipogenesis of visceral fat, Nature Communications 6, Article number: 7671 DOI: 10.1038/ncomms8671

Journal information: Nature Communications
Citation: Scientists discover possible 'obesity gene' (2015, August 10) retrieved 28 March 2024 from https://medicalxpress.com/news/2015-08-scientists-obesity-gene.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Toward a safe antiobesity drug that could block fat absorption

239 shares

Feedback to editors