Plaque afflicts more than just teeth. A cholesterol-infused version of the stuff can also coat the inner lining of arteries, sometimes hardening and narrowing those canals to the point that oxygen-ferrying blood slows and ...
Oct 31, 2023
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Two widely used statins, rosuvastatin and atorvastatin, are equally effective at preventing heart attacks, strokes and death in people with coronary artery disease. But while rosuvastatin treatment is associated with lower ...
Oct 18, 2023
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For older versus younger adults, low- to moderate-intensity statins are associated with a greater reduction in low-density lipoprotein cholesterol (LDL-C), according to a study published online Aug. 1 in the Annals of Internal ...
Aug 1, 2023
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Rosuvastatin is associated with increased risks for hematuria, proteinuria, and kidney failure with replacement therapy (KFRT) compared with atorvastatin use, according to a study published online July 19 in the Journal of ...
Aug 18, 2022
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Results from a large clinical trial indicate that patients with rheumatoid arthritis are likely to experience the same level of cardiovascular benefits from statins as other individuals, without additional risks. The findings ...
Apr 15, 2019
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Brazilian researchers have discovered that a drug regularly prescribed to control cholesterol can also be used to treat cachexia, or wasting syndrome, a condition characterized by rapid weight loss and muscle atrophy associated ...
Mar 20, 2019
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(HealthDay)—For patients with hypertriglyceridemia, low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) reductions depend of the choice and dose of statin, according to research published in the May 1 issue ...
Apr 20, 2016
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(HealthDay)—For Japanese patients who have undergone percutaneous coronary intervention (PCI), atorvastatin plus ezetimibe is associated with improved outcomes versus atorvastatin alone, according to a study published in ...
Jul 29, 2015
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Acute kidney injury often arises after major surgery because the kidneys can be deprived of normal blood flow during the procedure. The use of contrast media, or dyes, can contribute to this problem.
Jan 20, 2015
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When it comes to cholesterol-lowering statin medications for patients with type 2 diabetes, rosuvastatin may be a better choice than atorvastatin, according to the findings of a new study presented today at ESC Congress 2014.
Sep 1, 2014
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Atorvastatin (INN) ( /əˌtɔrvəˈstætən/), sold by Pfizer under the trade name Lipitor, is a member of the drug class known as statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.
Atorvastatin was first synthesized in 1985 by Bruce Roth while working at Parke-Davis Warner-Lambert Company (now Pfizer). With 2008 sales of US$12.4 billion, Lipitor was the top-selling branded pharmaceutical in the world. U.S. patent protection was scheduled to expire in June 2011. However, Pfizer made an agreement with Ranbaxy Laboratories to delay the generic launch in the U.S. until November 30, 2011.
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