Aging may be less about specific "aging genes" and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers in an opinion piece ...
Mar 21, 2024
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A new research paper titled "Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes" has been published in Aging.
Dec 19, 2023
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Three decades after discoveries linking mutations in the BRCA1 gene to breast and ovarian cancer susceptibility, research led by Mays Cancer Center at The University of Texas Health Science Center at San Antonio (UT Health ...
Oct 6, 2023
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Around half of the genome is made up of transposable elements or 'jumping genes' that derive from ancient viral integrations. They persist in various states of decay like an old fashioned 'pull your own' junkyard where parts ...
Over time, we accumulate genetic damage that accelerates the aging process, increasing the risk of carcinogenesis. DNA is continually challenged by genotoxic factors that affect its fragile structure, inhibiting cell functions. ...
Jun 1, 2021
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Fanconi anemia (FA) is a genetic disease affecting small children characterized by bone-marrow failure, developmental abnormalities and predisposition to multiple forms of cancer. The molecular mechanisms behind FA are inherited ...
Oct 14, 2020
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Our cells have several ways to repair DNA that breaks when the cells divide. However, genetic mutations can disable these DNA repair mechanisms, destabilize the cells, and trigger cancer. In a paper published today in the ...
Jun 4, 2020
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Through a global gene expression analysis (transcriptomic), the researchers were able to find and confirm a genetic signature common to genodermatoses in patients' cells. The profile targets cellular activation and alteration ...
Mar 5, 2019
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Mutations driving cancer development leave behind specific 'scars," so-called mutational signatures, in the genome. In principle, they allow for profiling of the cancer type and its development—but the noisy environment ...
May 9, 2018
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Mitochondria are cellular organelles with their own DNA. Their role in power generation makes them susceptible to oxidative damage, including the formation of DNA-damaging chemical complexes called adducts.
Feb 23, 2018
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