Immunology

Faulty DNA disposal system found to cause inflammation

Cells in the human body contain power-generating mitochondria, each with their own mtDNA—a unique set of genetic instructions entirely separate from the cell's nuclear DNA that mitochondria use to create life-giving energy. ...

Diseases, Conditions, Syndromes

Researchers trace a form of lupus back to a single mutation

Sometimes a single mutation in our genetic make-up is enough to cause disease. This is also the case with the autoimmune disease lupus. Lupus causes severe inflammation throughout the body and can have a serious impact on ...

Immunology

Mysterious fats reprogram the memory of innate immune cells

Researchers at Radboudumc have unveiled a fascinating connection between sphingolipids, mysterious fats named after the "Sphinx," and the memory of cells from the innate immune system. This discovery provides new avenues ...

Diseases, Conditions, Syndromes

Severe COVID-19 may lead to long-term innate immune system changes

Severe COVID-19 may cause long-lasting alterations to the innate immune system, the first line of defense against pathogens, according to a small study. These changes may help explain why the disease can damage so many different ...

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Innate immune system

The innate immune system comprises the cells and mechanisms that defend the host from infection by other organisms, in a non-specific manner. This means that the cells of the innate system recognize and respond to pathogens in a generic way, but unlike the adaptive immune system, it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life.

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