The therapeutic drug rapamycin, which is normally used in cancer therapy and after organ transplants, can extend the lifespan and health span of laboratory animals. Understanding how rapamycin extends lifespan is important, ...
Feb 28, 2024
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A new research perspective titled "Towards disease-oriented dosing of rapamycin for longevity: does aging exist or only age-related diseases?" has been published in Aging.
Aug 2, 2023
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A new research perspective was published in Oncotarget entitled "Cancer prevention with rapamycin."
Apr 17, 2023
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Each year about 1.5 million people in the U.S. survive a traumatic brain injury due to a fall, car accident, or a sports injury, which can cause immediate and long-term disability.
Apr 4, 2023
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The effect of medicines on women and men can differ significantly. This also applies to the currently most promising anti-aging drug rapamycin, as researchers from the Max Planck Institute for Biology of Ageing in Cologne ...
Dec 1, 2022
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Imagine you could take a medicine that prevents the decline that come with age and keeps you healthy. Scientists are trying to find a drug that has these effects. The current most promising anti-aging drug is rapamycin, known ...
Aug 29, 2022
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Researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have found that oral administration of rapamycin to an Alzheimer's disease mouse model causes an increase in beta (β)-amyloid ...
Jun 7, 2022
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A new research perspective published in Oncoscience by Mikhail Blagosklonny, M.D., Ph.D., looks at the possibility of immediate life extension using rapamycin.
May 11, 2022
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Everyone wants to stay fit and healthy as they grow old. But as we age, our body degrades, our muscles shrink and strength declines. Some older people suffer from excessive muscle loss, a condition known as sarcopenia. University ...
Apr 20, 2022
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New research to be presented this week virtually at the American Physiological Society's (APS) annual meeting at Experimental Biology 2021 explores the positive and negative effects of lifespan-extending drugs on mitochondrial ...
Apr 27, 2021
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Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. A macrolide, sirolimus was first discovered as a product of the bacterium Streptomyces hygroscopicus in a soil sample from Easter Island — an island also known as "Rapa Nui", hence the name. It is marketed under the trade name Rapamune by Wyeth.
Sirolimus was originally developed as an antifungal agent. However, this was abandoned when it was discovered that it had potent immunosuppressive and antiproliferative properties.
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