Alzheimer's disease & dementia

Experimental Alzheimer's drug improves memory in mice

An experimental drug known as A03, which was previously developed to treat depression, increases the levels of the enzyme Sirtuin1, or SirT1, and improves memory in mice. The mice were genetically modified to have a protein ...

Diseases, Conditions, Syndromes

New mechanism activates bone-building cells in osteoperosis

The number of osteoporosis medications that promote bone formation are few compared to those that suppress bone resorption. A research group led by Kumamoto University scientists has discovered that the gene SIRT7 is important ...

Medical research

Protein Partners

As proteins go, the sirtuins are the cool kids, attracting attention for their connection to aging and age-related disorders. Sirtuins' home base, mitochondria, is also known for its role in health and disease.

Medical research

3 Questions: MIT biologist on new resveratrol study

In the early 1990s, MIT professor Leonard Guarente discovered that sirtuins, a class of proteins found in nearly all animals, protect against the effects of aging in yeast; similar effects have since been seen in many other ...

Medical research

Proteins linked to longevity may be involved in mood control

(Medical Xpress) -- Over the past decade, MIT biologist Leonard Guarente and others have shown that very-low-calorie diets provoke a comprehensive physiological response that promotes survival, all orchestrated by a set of ...

Medical research

Compound improves health, increases lifespan of obese mice

(Medical Xpress) -- Researchers have reported that obese male mice treated with a synthetic compound called SRT1720 were healthier and lived longer compared to non-treated obese mice. The experimental compound was found to ...