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Alzheimer's disease & dementia news
Genetics
Study finds RNA modification is responsible for disruption of mitochondrial protein synthesis in Alzheimer's disease
A team of researchers at Johannes Gutenberg University Mainz (JGU) has identified a mechanism that causes mitochondrial dysfunction in Alzheimer's patients resulting in a reduction of the supply of energy to the brain.
6 hours ago
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Alzheimer's disease & dementia
Nanomaterial that mimics proteins could be basis for new neurodegenerative disease treatments
A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins ...
6 hours ago
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National trial safely scales back prescribing of a powerful antipsychotic for the elderly
Warning letters from Medicare can safely cut prescribing of a powerful but risky antipsychotic, according to a new study at Columbia University Mailman School of Public Health. Researchers used Medicare data to study the ...
8 hours ago
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Q&A: Alzheimer's and Arab Americans—more research needed
Middle Eastern and Arab American populations may have higher rates of Alzheimer's disease and related cognitive impairments, but researchers don't exactly know because these populations aren't identifiable in national datasets.
3 hours ago
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Better heart health at midlife linked to less cognitive decline in Black women
Better heart health may mean middle-aged Black women are less likely to show cognitive decline than those with poor heart health, a study has found.
5 hours ago
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New device improves stem cell generation and chance for accessible Alzheimer's cell therapy
Researchers in Sweden say they have improved on a technique for converting regular skin cells into neural stem cells—an advance that they say helps close the gap for accessible personalized cell-based therapies for Alzheimer's ...
Apr 24, 2024
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Genetic association study opens up new treatment avenues for Pick's disease, a rare form of early-onset dementia
Pick's disease, a neurodegenerative disease of unknown genetic origin, is a rare type of frontotemporal dementia that affects people under the age of 65. The condition causes changes in personality, behavior and sometimes ...
Apr 24, 2024
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Alzheimer's drug development pipeline: Positive results, new insight on biomarkers position 2024 as 'learning year'
The world of Alzheimer's treatments is at an inflection point as more potential drugs make their way out of clinical trials.
Apr 24, 2024
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Longest study to date assesses cognitive impairment over time in adults with essential tremor
Essential tremor, a nervous system disorder that causes rhythmic shaking, is one of the most common movement disorders. A new study published in the Annals of Neurology reveals details on the increased risk of mild cognitive ...
Apr 24, 2024
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Brain neurons re-entering the cell cycle age quickly and shift to senescence, particularly in neurodegenerative disease
Post-mitotic neurons in the brain that re-enter the cell cycle quickly succumb to senescence, and this re-entry is more common in Alzheimer's disease, according to a new study published April 9 in the open-access journal ...
Apr 23, 2024
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Innovative microscopy demystifies metabolism of Alzheimer's
Alzheimer's disease causes significant problems with memory, thinking and behavior and is the most common form of dementia, affecting more than 50 million people around the world each year. This number is expected to triple ...
Apr 23, 2024
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Using AI to improve Alzheimer's treatment through the 'gut-brain axis'
Cleveland Clinic researchers are using artificial intelligence to uncover the link between the gut microbiome and Alzheimer's disease.
Apr 22, 2024
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Study shows how depletion of mitochondria in axons can directly lead to protein accumulation
Researchers from Tokyo Metropolitan University have identified how proteins collect abnormally in neurons, a feature of neurodegenerative diseases like Alzheimer's. The research is published in the journal eLife.
Apr 22, 2024
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Occupations that are cognitively stimulating may be protective against later-life dementia
People with a history of cognitively stimulating occupations during their 30s, 40s, 50s, and 60s had a lower risk of mild cognitive impairment (MCI) and dementia after age 70, according to a new study from Columbia University ...
Apr 20, 2024
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Dementia treatments linked with serious side effects: Study
Several antipsychotic treatments given to patients with dementia have been linked to serious side effects including heart failure, a study published Thursday has found.
Apr 20, 2024
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Geneticists develop world's first bioinformatic tool to identify amyloids consisting of multiple copies of same protein
Scientists from St Petersburg University and the University of Montpellier have developed the first software enabling the prediction of pairs of proteins in amyloid fibrils capable of co-aggregation, i.e. a process by which ...
Apr 19, 2024
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Obesity-induced cognitive decline: Role of brain oxidation and tocotrienols
Obesity has become a pressing worldwide health issue, with rates steadily rising over recent decades. Beyond its well-documented associations with physical health issues, such as cardiovascular disease and diabetes, obesity ...
Apr 18, 2024
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Study links lack of diversity in Alzheimer's disease clinical trials to differences in amyloid levels
It's long been recognized that some of the groups most likely to get dementia, including African Americans and Hispanics, are greatly underrepresented in clinical trials. Now a new USC study shows that people from certain ...
Apr 17, 2024
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How Alzheimer's disease progresses faster in people with Down syndrome
Nearly all adults with Down syndrome will develop evidence of Alzheimer's disease by late middle age. A new study by researchers at Washington University School of Medicine in St. Louis shows that the disease both starts ...
Apr 17, 2024
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Antipsychotics for dementia linked to more harms than previously acknowledged
Antipsychotic use in people with dementia is associated with elevated risks of a wide range of serious adverse outcomes including stroke, blood clots, heart attack, heart failure, fracture, pneumonia, and acute kidney injury, ...
Apr 17, 2024
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