Don't forget that many studies have demonstrated that people's brain wiring is always changing as a result of their experience/training. To take some examples: studies have shown that as taxi drivers do their jobs, their brain/neurons change. Jugglers gain more grey matter in certain areas of the brain as a RESULT of engaging in this activity. Various psychological habits, choices, etc., also change the brain. For example, research has shown that impulsivity trait results in reductions in gray matter. Mindfulness practices (that result in reductions in impulsivity) change the structure and function of the brain in positive ways (e.g. increases in gray matter and cortical thickness). There are many more examples.