Experimental therapy eases Alzheimer's signs, symptoms in mice
A new cellular therapy improved learning and memory in mice with Alzheimer's disease, researchers report.
Dec 29, 2023
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Molecular Neurodegeneration is an open access, peer-reviewed online journal that encompasses all aspects of neurodegeneration research at the molecular and cellular levels. Neurodegenerative diseases collectively refer to neurological disorders that result from neurodegeneration and include, but are not limited to, Alzheimer's disease, Parkinson disease, Huntington disease, and prion diseases. These diseases, which are often associated with advanced aging and display varying degrees of dementia, have become a significant public health issue as humans live longer and the aging population grows larger. Recent advances in the molecular and cellular mechanisms underlying the pathogenesis of these neurodegenerative disorders have allowed for a better understanding of the disease mechanisms.
A new cellular therapy improved learning and memory in mice with Alzheimer's disease, researchers report.
Dec 29, 2023
0
80
Researchers at Weill Cornell Medicine have demonstrated how amyloid beta, a peptide associated with Alzheimer's disease, can interact with a protein receptor on immune cells in the brain. This triggers a reaction that damages ...
Nov 8, 2023
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Researchers at St Vincent's Hospital in Sydney have achieved a breakthrough in our understanding dementia and new way forward to its treatment. Through their discovery, the team restored nerve cell connections (synapses) ...
Sep 28, 2023
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A new study shows that the activation of the brain's immune defense cells—astrocytes—in the early stages of Alzheimer's disease could be tracked early with a brain PET scanner and is linked to changes that can be detected ...
Sep 12, 2023
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In the human central nervous system, there are tiny cells that—for most people, most of the time—provide important immune protection to the brain and spinal cord. Occasionally these microglia cells run terribly awry, ...
May 30, 2023
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To date, the search for effective treatments for dementia has yielded only disappointments. Many recent drug candidates target the tau protein, which aggregates and forms tangles in patients' brain tissue and is involved ...
Apr 7, 2023
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Indiana University School of Medicine researchers are investigating how the deficiency of a gene in immune cells can shape the progression of Alzheimer's disease.
Nov 3, 2022
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Alzheimer's disease (AD) currently has no cure and is predicted to affect over 100 million people worldwide by 2050. Ongoing research is focused on two key neurotoxic proteins: amyloid beta (Aβ) and tau. While these proteins ...
Oct 17, 2022
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Researchers with the Peter O'Donnell Jr. Brain Institute at UT Southwestern have identified a new protein implicated in cell death that provides a potential therapeutic target that could prevent or delay the progress of neurodegenerative ...
Apr 27, 2021
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Researchers at Karolinska Institutet in Sweden have studied the incidence and regional distribution of Alzheimer's disease biomarkers in the brains of people with Down's syndrome. The results can bring new possibilities for ...
Nov 23, 2020
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