Brain cancer study reveals therapy clues
Researchers have pinpointed two key molecules that drive the growth of an aggressive type of adult brain cancer.
The findings shed light on the mechanisms that underpin brain cancer progression and could eventually reveal targets for the development of much-needed therapies, researchers say.
The team identified two molecules that are produced at high levels by the cells – called FOXG1 and SOX2.
Similar levels of these molecules are found in brain stem cells and are a defining feature of these cells.
The researchers found that SOX2 drives glioblastoma cells to keep dividing, a hallmark of cancer.
FOXG1 stops the cells from responding to other signals that would usually point them towards becoming specialised, the team found.
"Brain cancer cells seem to be hijacking important cell machinery that is used by normal brain stem cells. The tactic they appear to use is to produce high levels of these key regulators. This locks the tumour cells into perpetual cycles of growth and stops them listening to the signals that normally control cell specialisation," says Dr Steve Pollard.
Both FOXG1 and SOX2 work by controlling when key target genes are switched on and off by the cell.
The researchers analysed which genes were affected and identified several factors that are involved in controlling cell division.
The insights could open the door to new therapies that stop or slow tumour growth, the researchers say.
"The next step will be for scientists to see if they can develop a way to stop glioblastoma cells from using these molecules as a way to survive and then to test it in clinical trials to see whether this affects tumour growth in people," says Dr Áine McCarthy
Glioblastoma is a fast-growing type of brain tumour. There are few options for treatment and only one in five patients will survive more than one year after diagnosis.
More information: Harry Bulstrode et al. Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators, Genes & Development (2017). DOI: 10.1101/gad.293027.116
Journal information: Genes & Development
Provided by University of Edinburgh