Neuroscience

New mechanism uncovered in early stages of Alzheimer's disease

Alzheimer's disease (AD) remains one of the most challenging and prevalent neurodegenerative disorders, affecting millions of individuals worldwide. In a new study published in Developmental Cell, researchers from the lab ...

Genetics

Newly found genetic variant defends against Alzheimer's disease

Columbia researchers have discovered a genetic variant that reduces the odds of developing Alzheimer's disease by up to 70% and may be protecting thousands of people in the United States from the disease. The study, "Rare ...

Alzheimer's disease & dementia

Human neuron model paves the way for new Alzheimer's therapies

Weill Cornell Medicine scientists have developed an innovative human neuron model that robustly simulates the spread of tau protein aggregates in the brain—a process that drives cognitive decline in Alzheimer's disease ...

Alzheimer's disease & dementia

Immunotherapy for Alzheimer's disease shows promise in mouse study

Alzheimer's disease starts with a sticky protein called amyloid beta that builds up into plaques in the brain, setting off a chain of events that results in brain atrophy and cognitive decline. The new generation of Alzheimer's ...

Genetics

Longevity scores show signs of resilience to certain diseases

Using data from four studies that connect genetic variants to lifespan, scientists have developed 11 different polygenic longevity scores (PLS) that predict both long life and resilience to some age-related conditions such ...

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