A single cell contains 2-3 meters of DNA, meaning that the only way to store it is to package it into tight coils. The solution is chromatin: a complex of DNA wrapped around proteins called histones. In the 3D space, this ...
Mar 15, 2023
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Pancreatic cancer is the third deadliest cancer in the United States, after lung and colorectal, though far less common. It is also among the hardest to effectively treat, with pancreatic cancer stem cells quickly developing ...
Jan 19, 2023
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Many diseases affect how cells are spatially organized in tissues, such as in Alzheimer's disease, where amyloid-β proteins clump together to form plaques in the brain. Studying how cells differ in various regions of tissue ...
Dec 8, 2022
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Scientists at the Francis Crick Institute have uncovered how a build-up of DNA molecules can impact survival chances in people with severe COVID-19 or sepsis, and have developed a tool that could be used to identify the patients ...
Nov 17, 2022
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National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell's ...
Oct 7, 2022
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The human heart is an intricate, complex organ and, like a car that starts sputtering, its function deteriorates for all sorts of reasons. Cardiomyopathy—any disease of the heart muscle that makes it pump blood less effectively—can ...
Oct 5, 2022
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Researchers from Children's Hospital of Philadelphia (CHOP) have used advanced three-dimensional mapping techniques at a microscopic level to identify a multitude of genetic variants and corresponding target gene pairings ...
Sep 6, 2022
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The structure of chromatin—the mixture of DNA and proteins that form chromosomes—can affect gene expression, and certain chromatin "readers" are important for monitoring this structure often in response to environmental ...
Aug 22, 2022
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Gene editing may be a potential treatment for anxiety and alcohol use disorder in adults who were exposed to binge drinking in their adolescence, according to the results of an animal study published in the journal Science ...
May 4, 2022
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Researchers have developed a new fluorescent label that gives a clearer picture of how DNA architecture is disrupted in cancer cells. The findings could improve cancer diagnoses for patients and classification of future cancer ...
Mar 4, 2022
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