Molecular analysis of a tumor biopsy from a proto-oncogene 1 receptor tyrosine kinase positive (ROS1+) patient with acquired crizotinib resistance revealed a novel mutation in the v-kit Hardy Zuckerman 4 feline sarcoma viral ...
Apr 11, 2016
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Understanding Li–Fraumeni syndrome (LFS)—a genetic disorder that substantially increases the risk of a young person developing cancer such as the bone cancer osteosarcoma—is a first step to improving diagnosis and counseling.
Jan 27, 2016
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A deadly form of T cell lymphoma is caused by an unusually large number gene deletions, making it distinct among cancers, a new Yale School of Medicine study shows.
Jul 21, 2015
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Multiplexed genetic screening for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements and subsequent biomarker-guided treatment is cost-effective compared with standard chemotherapy ...
Jan 29, 2015
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In 1982, the gene TRK was shown to cause a small percentage of colon cancers. In 2013 and 2014, next-generation sequencing of tumor samples found fusions of the TRK family of genes in at least 11 tumor types, including lung, ...
Dec 29, 2014
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One of the deadliest forms of paediatric brain tumour, Group 3 medulloblastoma, is linked to a variety of large-scale DNA rearrangements which all have the same overall effect on specific genes located on different chromosomes. ...
Jun 23, 2014
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(Medical Xpress)—Patients with lung cancer who also have a specific gene rearrangement do better on a new targeted therapy compared with standard chemotherapy, according a study by University of Manchester scientists.
Jan 13, 2014
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A University of Colorado Cancer Center study published online ahead of print in the journal Molecular Cancer Research shows that ALK and ROS1 gene rearrangements known to drive subsets of lung cancer are also present in some ...
Dec 17, 2013
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Retinitis pigmentosa (RP) is a genetic disease that causes progressive loss of vision and is caused by mutations in more than 50 genes. Conventional methods for identification of both RP mutations and novel RP genes involve ...
Sep 16, 2013
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Generally, FDA-approved clinical trials progress through three phases: the first shows safety, the second starts to explore effects and the third seeks to prove a drug's superiority over existing treatments. But when a drug's ...
Aug 8, 2013
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