Diabetes

Key protein accelerates diabetes in two ways

The same protein tells beta cells in the pancreas to stop making insulin and then to self-destruct as diabetes worsens, according to a University of Alabama at Birmingham (UAB) study published online today in the journal ...

Genetics

Science of genome-sequencing marks 10 years

A decade after completion of the Human Genome Project on April 14, 2003, a top official of the National Institutes of Health surveyed the rarefied view from that mountaintop:

Genetics

Not dead yet: Junk DNA is back

A controversy at last: most of our DNA is junk, no it isn't, yes it is. Actually, I think it is – up to 90% really is junk.

Overweight & Obesity

Long noncoding RNAs control development of fat cells

Whitehead Institute researchers have identified a previously unrecognized layer of genetic regulation that is necessary for the generation of undesirable white fat cells. When this regulation is disrupted, white fat cells ...

Genetics

Chromatin marks the spot in search for disease pathways

In September 2012, the Encyclopedia of DNA Elements (ENCODE) Project Consortium, a multi-institution collaboration that included the Broad Institute, capped off nine years of research with a flurry of papers that characterized ...

Medical research

'Junk DNA' can sense viral infection

Once considered unimportant "junk DNA," scientists have learned that non-coding RNA (ncRNA) — RNA molecules that do not translate into proteins — play a crucial role in cellular function. Mutations in ncRNA are ...

Genetics

Breakthrough study finds 'master switches' in colon cancer

A team of researchers at Case Western Reserve University School of Medicine have identified a new mechanism by which colon cancer develops. By focusing on segments of DNA located between genes, or so-called "junk DNA," the ...

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